Basic Information
VIS ID
TVIS10011515
Fusion event
HBV-UBE2Q2P2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1854
Orient
+
Integrated sequence
TTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCA| |TGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGT
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
83074878/82406147 (Hg38)
End
83074878/82406147 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
UBE2Q2P2
Nearest miRNA
hsa-mir-10393/Upstream/1408674; hsa-mir-11181/Downstream/661188;
Nearest TSS
ENST00000557528/Upstream/56672; ENST00000558668/Downstream/23871;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/50188, chr15-CpG: 81/Downstream/38993
Upstream sequence
aaagatcttttcatttagtcatcatagccactgtgtgaaataggtgctgtttatactttagagatatgaaaaacttttcatattttatagatatgaaatg
Downstream sequence
agttcaggtttacatagctaggaggtaataTTTTTATAAACTTGATTTTTTTCCCCCTTCAAAGTCTAGTGCAGTCTTTAAAACCTCTAGTTTCACATGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate