Basic Information
VIS ID
TVIS10011516
Fusion event
HBV-UBE2Q2P2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1826
Orient
-
Integrated sequence
AAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTT| |TCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAA
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
83074898/82406167 (Hg38)
End
83074898/82406167 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
UBE2Q2P2
Nearest miRNA
hsa-mir-10393/Upstream/1408694; hsa-mir-11181/Downstream/661168;
Nearest TSS
ENST00000557528/Upstream/56692; ENST00000558668/Downstream/23851;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/50208, chr15-CpG: 81/Downstream/38973
Upstream sequence
atcatagccactgtgtgaaataggtgctgtttatactttagagatatgaaaaacttttcatattttatagatatgaaatgagttcaggtttacatagcta
Downstream sequence
ggaggtaataTTTTTATAAACTTGATTTTTTTCCCCCTTCAAAGTCTAGTGCAGTCTTTAAAACCTCTAGTTTCACATGACCAAAAAGTAGTTCCATTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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