VISDB Viral Integration Site DataBase

VIS ID

TVIS10011519

Fusion event

HBV-POLR3E integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1794

Orient

-

Integrated sequence

ACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAA| |ATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGC

Chromosome

chr16

Cytoband

p12.2

Reference genome

Start

End

22334471/22323150 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-98-5p ; hsa-mir-320a ; hsa-mir-34a-5p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6516-3p ; hsa-mir-584-5p ; hsa-mir-1206 ; hsa-mir-31-3p ; hsa-mir-873-3p ; hsa-mir-4495 ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-30d-5p ; hsa-mir-30c-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p

Nearest miRNA

hsa-mir-1225/Upstream/817015; hsa-mir-11401/Downstream/1879966;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/25106, chr16-CpG: 30/Downstream/2677

Upstream sequence

GGCCCTGGCCTCTGCCTTTCTCCTCCTTCCTCTCAGAAGCCTGGAGTCTCGGGCTGGAAAGAACCTTCCAGTTCCTCTAGCGCAGTCGGGGGGTGGGTCA

Downstream sequence

AGAAGCACGTTTCATTCGGCCTGAGTGGTGGTTTAGAAATATTGCCTTGGTTGTCAGATTTTATAAATTGAAATTTTGATGTAAAAAAAATCTTGATGCT