Basic Information
VIS ID
TVIS10011520
Fusion event
HBV-CASC22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2042
Orient
+
Integrated sequence
AGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCA| |TTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCG
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
52308923/52275011 (Hg38)
End
52308923/52275011 (Hg38)
Orient
+
Location type
Intronic
Target gene
CASC22
Nearest miRNA
hsa-mir-1225/Upstream/1532634; hsa-mir-11401/Downstream/3970509;
Nearest TSS
ENST00000527434/Upstream/3439; ENST00000564361/Downstream/170715;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1118662, chr16-CpG: 125/Downstream/270713
Nearby gene
LINC00919(-189902) ; TOX3(+162995) ;
Upstream sequence
AGCTCTAAGGTAGCCTATGTGAATGAGCAATGGAGAAAGAGGGAAAAACATAAGGAGTTAACCCCAAAAAATTggccatgggtggtggctcatgcctgta
Downstream sequence
atcccagcactttgggaggccaaggagggtgaatcacttgaggtcaggacttcaaaaccagcctggctaacatggtaaaactcctgtctctactaaaata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate