Basic Information
VIS ID
TVIS10011526
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
1820232/1820231 (Hg38)
End
1820232/1820231 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-8078/Upstream/1707892; hsa-mir-1-2/Downstream/2065122;
Nearest TSS
ENST00000575820/Upstream/39902; ENST00000575515/Downstream/86415;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/910658, chr18-CpG: 33/Downstream/751056
Nearby gene
LINC00470(-460602) ; METTL4(+717292) ;
Upstream sequence
AATTttataattcttattaaaattataattttataattcttattaaaattataattttataattcttattgaaattataattttataattcttattgaaa
Downstream sequence
ttataattttataattcttattgaaattataattttataattcttattgaaattataaataattttataattcttattGaaattataaataattttatat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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