Basic Information
VIS ID
TVIS10011528
Fusion event
HBV-CCDC178 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1972
Orient
+
Integrated sequence
TCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCT| |TTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCA
Host Sequence
Chromosome
chr18
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
30890385/33310421 (Hg38)
End
30890385/33310421 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18A
Target gene
CCDC178
Nearest miRNA
hsa-mir-1-2/Upstream/3011461; hsa-mir-122/Downstream/2281316;
Nearest TSS
ENST00000575820/Upstream/43456; ENST00000647014/Downstream/35801;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/538082, chr18-CpG: 45/Downstream/130125
Upstream sequence
gtgtatgtcatgataaagtttgtgaaagaacatttaaaagataaattgtacatggaattaagttggctataattaaaaaggaattactggctggccactg
Downstream sequence
tatatcacacctgtaatctcagcactttgggggccaagggtagattgcttgagcccagaagtttgagatcaacctgggaagcaagctgaaaccccatcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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