Basic Information
VIS ID
TVIS10011531
Fusion event
HBV-LINC01630 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2067
Orient
+
Integrated sequence
CTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTC| |AGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATG
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
48954573/51428203 (Hg38)
End
48954573/51428203 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC01630
Nearest miRNA
hsa-mir-1-2/Upstream/1301640; hsa-mir-122/Downstream/1808898;
Nearest TSS
ENST00000575820/Upstream/36161; ENST00000635103/Downstream/132618;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/230148, chr18-CpG: 29/Downstream/913804
Upstream sequence
ACTTCCCTAGAACCACTCCACTGCCGAGGCCAGCATGTTGAAGACAGCATTAGTTAAAAGCCAGAACATACAGAATTCTAGGCAGGGGCCACGGGGCAAT
Downstream sequence
GAGTAGATTCCAAGGCATGGCAGGGAGGAGAATATGACAAGGACaacagctaccagtagtcaccattcctacttctgttcctatttcctctttaaccaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate