VISDB - VIS Detail

Basic Information

VIS ID

TVIS10011537

Fusion event

HBV-CEP89 integration

Validated

Detection method

NGS

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

30271481

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Region type

X protein|

Start

1806

Orient

Integrated sequence

ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG

Host Sequence

Chromosome

chr19

Cytoband

q13.11

Reference genome

GRCh37/hg19

Start

33424263/32933357 (Hg38)

End

33424263/32933357 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA19A

Target gene

CEP89

miRNAs that regulate target gene

hsa-mir-193a-3p ; hsa-mir-6842-3p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-4433a-3p ; hsa-mir-6504-3p ; hsa-mir-889-5p ; hsa-mir-4433b-3p ; hsa-mir-4700-3p ; hsa-mir-7153-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-532-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1224-3p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-6513-3p ; hsa-mir-4714-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5698 ; hsa-mir-7156-3p ; hsa-mir-143-5p ; hsa-mir-3622b-5p ; hsa-mir-6499-3p ; hsa-mir-1184 ; hsa-mir-1304-3p ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-656-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6765-3p

Nearest miRNA

hsa-mir-10395/Upstream/12534003; hsa-let-7e/Downstream/2189343;

Nearest TSS

ENST00000633603/Upstream/54936; ENST00000590281/Downstream/26595;

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/212183, chr19-CpG: 48/Downstream/38452

Upstream sequence

GAATTTCTTTAGTGTAATAATGATATAGCAGATGAAATCAAATCTCAACAAACATAAGGATATTAACAAAAAAACCTGAAATATTACAACATAAATTACC

Downstream sequence

AACACAAATATCACAACATAAAATATTAACTCTCAAAATAATTGAGTGAAGTCCTGCTCATTCCTCTAATAAAGGCACTCTGTCTGTCCCCACCTTCCTG

Reference

Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.