VISDB - VIS Detail

Basic Information

VIS ID

TVIS10011538

Fusion event

HBV-CEP89 integration

Validated

Detection method

NGS

Data source

Curated

Sample type

Nontumor

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

30271481

Virus Sequence

Virus name

HBV

Reference genome

NC_003977

Region type

precore/core protein|Core and e antigen|

Start

2290

Orient

Integrated sequence

TTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTC| |CAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCC

Host Sequence

Chromosome

chr19

Cytoband

q13.11

Reference genome

GRCh37/hg19

Start

33424316/32933410 (Hg38)

End

33424316/32933410 (Hg38)

Orient

Location type

Intronic

Fragile sites / regions

FRA19A

Target gene

CEP89

miRNAs that regulate target gene

hsa-mir-193a-3p ; hsa-mir-6842-3p ; hsa-mir-6807-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-3922-3p ; hsa-mir-3176 ; hsa-mir-4433a-3p ; hsa-mir-6504-3p ; hsa-mir-889-5p ; hsa-mir-4433b-3p ; hsa-mir-4700-3p ; hsa-mir-7153-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-532-3p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1224-3p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-6513-3p ; hsa-mir-4714-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-5698 ; hsa-mir-7156-3p ; hsa-mir-143-5p ; hsa-mir-3622b-5p ; hsa-mir-6499-3p ; hsa-mir-1184 ; hsa-mir-1304-3p ; hsa-mir-103b ; hsa-mir-5693 ; hsa-mir-6890-3p ; hsa-mir-7705 ; hsa-mir-6854-5p ; hsa-mir-509-5p ; hsa-mir-509-3-5p ; hsa-mir-4418 ; hsa-mir-656-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6765-3p

Nearest miRNA

hsa-mir-10395/Upstream/12534056; hsa-let-7e/Downstream/2189290;

Nearest TSS

ENST00000633603/Upstream/54989; ENST00000590281/Downstream/26542;

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/212236, chr19-CpG: 48/Downstream/38399

Upstream sequence

ATAAGGATATTAACAAAAAAACCTGAAATATTACAACATAAATTACCAACACAAATATCACAACATAAAATATTAACTCTCAAAATAATTGAGTGAAGTC

Downstream sequence

CTGCTCATTCCTCTAATAAAGGCACTCTGTCTGTCCCCACCTTCCTGTGACGACGCCTTCTCAGCCTCTTTGAGCTTTCTCTTCTCTTTTTCCATTCCCT

Reference

Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.