Basic Information
VIS ID
TVIS10011539
Fusion event
HBV-LOC105372405 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1703
Orient
-
Integrated sequence
CGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGG| |CATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTG
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
42151426/41647505 (Hg38)
End
42151426/41647505 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
LOC105372405
Nearest miRNA
hsa-mir-10395/Upstream/1277598; hsa-let-7e/Downstream/222122;
Nearest TSS
ENST00000633603/Upstream/20431; ENST00000460121/Downstream/40662;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3243, chr19-CpG: 51/Downstream/197107
Nearby gene
CEACAM4(-17984) ; CEACAM7(+25809) ;
Upstream sequence
tgacagggcctcgctctgtcatccaggctggagtgcaatggtgcaactatgctcaccgcagcctcaaccacctccagttcatataaccctctgcctccgc
Downstream sequence
cttccagtagctggaacctcaagggcacaccaccgcacctggctaattttttaaaaaattttctagagacagggtctcactttgttgccagggctggtct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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