Basic Information
VIS ID
TVIS10011543
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1832
Orient
+
Integrated sequence
TGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCT| |CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA
Host Sequence
Chromosome
chr2
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
143552682/142795113 (Hg38)
End
143552682/142795113 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/2208428; hsa-mir-10b/Downstream/6535165;
Nearest TSS
ENST00000437798/Upstream/663412; ENST00000410015/Downstream/82385;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/664129, chr2-CpG: 111/Downstream/1141650
Nearby gene
LRP1B(-663412) ; KYNU(+82513) ;
Nearest cancer related gene
LRP1B(TSG, -663412) ;
Upstream sequence
TTTGAGTGCTCTATCCATAATGGCCTTAAGTGTATCTTTTACTAAATCAATCAAACTGAAGTCCCAATAATTCAAGAGAAATCCAGTCCATTACCACCTC
Downstream sequence
AACCTTTGACTTCTCAGCTTCTTTTGCCAAATTCTCACTTCATTAAAGTGCTACTAAAATGAATTCCTTTGTCACATGTCTCCACTACTCTACATTAAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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