Basic Information
VIS ID
TVIS10011547
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1779
Orient
-
Integrated sequence
CAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGG| |AGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGC
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
154245492/153388978 (Hg38)
End
154245492/153388978 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-128-1/Upstream/2020567; hsa-mir-10b/Downstream/5797857;
Nearest TSS
ENST00000437798/Upstream/51273; ENST00000434213/Downstream/89830;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/669939, chr2-CpG: 88/Downstream/88957
Nearby gene
ARL6IP6(-627725) ; RPRM(+88360) ;
Nearest cancer related gene
RPRM(TSG, +88360) ;
Upstream sequence
ACACTGGGGTTGATTGATTTAAAAAAACTGAGATGGAGCCTGGGGTCTACTTGGAGAGAGTAGAAGTAGCTCCTCAGATAGGGCTAACAGCCATTTCCTC
Downstream sequence
AGGGAAACAATGAGAAATCTTGGCTATAAGAAAATGAGTTAGATCTGCCGCAGAATTCTGTCCTAGGAAACAGCTCCTGTCAATACAGTTCATCATATGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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