Basic Information
VIS ID
TVIS10011548
Fusion event
HBV-LINC01934 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1819
Orient
+
Integrated sequence
TTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGC| |AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA
Host Sequence
Chromosome
chr2
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
182000597/181135870 (Hg38)
End
182000597/181135870 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
LINC01934
Nearest miRNA
hsa-mir-10b/Upstream/1274962; hsa-mir-1244-1/Downstream/169723;
Nearest TSS
ENST00000437798/Upstream/11928; ENST00000645719/Downstream/37854;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/154671, chr2-CpG: 119/Downstream/321164
Nearby gene
UBE2E3(-72447) ; MIR4437(+169723) ;
Upstream sequence
tcatacctcaaaatgataaagacatatttgatgaactcacagttaatatcatactgaacagataaaaattaaaagttgttctactaacatctggaacaag
Downstream sequence
aaaaggatgacttcttttaccacttttattcaacatagttctagaagtcctcgacagagcagttaggcaaggtaaagaaataaatggtatctgaatagga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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