Basic Information
VIS ID
TVIS10011556
Fusion event
HBV-TRAPPC12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2246
Orient
-
Integrated sequence
GAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGT| |TATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTT
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
3456925/3453154 (Hg38)
End
3456925/3453154 (Hg38)
Orient
-
Location type
Intronic
Target gene
TRAPPC12
miRNAs that regulate target gene
hsa-mir-1914-5p ; hsa-mir-744-5p ; hsa-mir-10a-5p
Nearest miRNA
hsa-mir-10b/Downstream/2521508;
Nearest TSS
ENST00000437798/Upstream/3958; ENST00000489032/Downstream/1458;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/4343, chr2-CpG: 18/Downstream/4729
Upstream sequence
ctggcaccggacatccctgttcttgtcactgcggcactttgcTCTGTGTGTGGAAAGCGTGAAGGGCCCCTGCAAATGGACATGATGCTGCCTCCTCCAC
Downstream sequence
AGGTTTATTTTTGTGAAATCAAACAGAATACTGTTTGTGCTTAAAAACCATCCTGCGCCCCCATCTGTAAAATACATCGTCCCCGGTACTTCCCAGCAGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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