Basic Information
VIS ID
TVIS10011558
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1925
Orient
+
Integrated sequence
TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA| |ATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCC
Host Sequence
Chromosome
chr2
Cytoband
p25.2
Reference genome
GRCh37/hg19
Start
6006397/5866265 (Hg38)
End
6006397/5866265 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Downstream/108397;
Nearest TSS
ENST00000437798/Upstream/53669; ENST00000436082/Downstream/459381;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/158836, chr2-CpG: 51/Downstream/371885
Nearby gene
SOX11(-164880) ; SILC1(+66422) ;
Nearest cancer related gene
SOX11(TSG, -164880) ;
Upstream sequence
aggggagggtgccctgggagcagagtcgagaggacctgcctctaccctgctgggtacagcaaggattCTGTGAGCTCTCTTCCTTCTTAAGCTGCTCTTC
Downstream sequence
CCCCAGAAGGTTATGCAGGTACAGGTCCTGACTGCTAGGGTCAATATACATCTCCTGATAACCTTTAGATCCAGGACACTGGAGGAAATCCTACACTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate