Basic Information
VIS ID
TVIS10011560
Fusion event
HBV-TEX37 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1577
Orient
-
Integrated sequence
GGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGAC| |CGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTC
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
88827184/88527666 (Hg38)
End
88827184/88527666 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
TEX37
Nearest miRNA
hsa-mir-1285-2/Upstream/445067; hsa-mir-10b/Downstream/284704;
Nearest TSS
ENST00000437798/Upstream/3015; ENST00000413234/Downstream/11054;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/74319, chr2-CpG: 22/Downstream/22251
Upstream sequence
cactttttgctaaacattatggcatattattcattttctgctgcatagtattacattgcatgaatatgccacagtgtaccgtatttgtcgtttctgtatc
Downstream sequence
tgtctcttcttattggtggacatttgggtgctttattcctactcttcccactcccaaatgctgcattgaagatgagataagtcacatcctaatgttcaag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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