Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011561
Fusion event
HBV-LBP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
Start
End
36973914/38345511 (Hg38)
Orient
+
Location type
upstream
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-103a-2/Upstream/2891414; hsa-mir-1-1/Downstream/171052;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/84471, chr20-CpG: 56/Downstream/89371
Upstream sequence
tcacttgagcccaggaagttgaggttgcagcgagcgatgttcatgccactggactcctgcttgagcaacagagtagactttgtctcaaaaaatgaaaaaa
Downstream sequence
gaaaaaaaaaTTGTACGTATCAACAAGCAAAAACTTTTTTAACACTTATAATTCTACCCCCACAACCAGAGACAATGCCTCATGACTCCTTGCTAAATAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.