Basic Information
VIS ID
TVIS10011566
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2105
Orient
+
Integrated sequence
CAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCT| |AGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTG
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
End
49785641/49391991 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-let-7a-3/Upstream/611638; hsa-mir-12114/Downstream/151402;
Nearby gene
LINC01310(-491443) ; C22orf34(+227649) ;
Upstream sequence
AGAGCAGTCATCGCCATTCTTGTCTATGTTCACTCAGAATGACCCACAAAAATACACCTGCCCACGTGCCAGAGCGACCCTCCCTGGCCAGGCCGGGCAT
Downstream sequence
GAATGGAAGGCATGAGCATTTGAGACACTAAATTGAGATTACAGGATCAACCCCTGTAAAGCTAGGAGGCAGAAGCCAATGTGGAAATTGGAATTACTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate