Basic Information
VIS ID
TVIS10011568
Fusion event
HBV-LOC105374039 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2604
Orient
+
Integrated sequence
CTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACT| |CACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTAT
Host Sequence
Chromosome
chr3
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
111199403/111480556 (Hg38)
End
111199403/111480556 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374039
Nearest miRNA
hsa-let-7g/Upstream/1877659; hsa-mir-12124/Downstream/632245;
Nearest TSS
ENST00000440867/Upstream/187837; ENST00000488054/Downstream/16539;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/408002, chr3-CpG: 21/Downstream/193924
Nearby gene
NECTIN3(-286387) ; CD96(+61523) ;
Upstream sequence
TAAAGTGAAGTTTGGTTTTACACCATGTCAATTTTGTATGTATTTATTTCCCTCAAGTTGCCCATTCTAGACGATGTCCTGGCATGTGTATTCAAAATGA
Downstream sequence
TCTGATCCCTTATATAGAGCAGAAGATGGCCAGAGACTAGCTACTAGTCTTACTTAGTCACTCTTCATTGATCAATTGTATCATTAGTTGATGCattcat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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