NAALADL2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011571
Fusion event
HBV-NAALADL2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr3
Cytoband
q26.31
Reference genome
GRCh37/hg19
Start
175011510/175293721 (Hg38)
End
175011510/175293721 (Hg38)
Orient
-
Location type
Intronic
Target gene
NAALADL2
Nearest miRNA
hsa-let-7g/Upstream/4186962; hsa-mir-1224/Downstream/75819;
Nearest TSS
ENST00000440867/Upstream/22625; ENST00000617758/Downstream/482612;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/852163, chr3-CpG: 133/Downstream/1902728
Upstream sequence
ctctgcctcctgggttcaaacaattctctgcctcagcttcccaagtagctgggaatacaggtgcccgccaccacacccagctaattttttttgtattttt
Downstream sequence
gaacctgaaagtgaaccctcatcagacacaaatttgccattgctttgatttcaggtttcccaggctctggaaatataagatatagattgttattgtttat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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