Basic Information
VIS ID
TVIS10011572
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1848
Orient
+
Integrated sequence
AGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCT| |TGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTAC
Host Sequence
Chromosome
chr3
Cytoband
q26.32
Reference genome
GRCh37/hg19
Start
176732997/177015209 (Hg38)
End
176732997/177015209 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/500058; hsa-mir-1224/Downstream/6871591;
Nearest TSS
ENST00000440867/Upstream/147371; ENST00000617758/Downstream/11206;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/2573651, chr3-CpG: 133/Downstream/181240
Nearby gene
NAALADL2(-1209569) ; TBL1XR1(+5545) ;
Upstream sequence
gcttcccaagtagctgggaatacaggtgcccgccaccacacccagctaattttttttgtatttttagtagagatggagtttcaccatcttgaccaatctg
Downstream sequence
gtcagtgctgaatttactgcaatataaaactgagcattaacagttgtggctacagaacaACACAAGGGAATGGGACATTCTGCTCCTCACATGTCATCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate