Basic Information
VIS ID
TVIS10011575
Fusion event
HBV-LOC105374287 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
193635758/193917969 (Hg38)
End
193635758/193917969 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105374287
Nearest miRNA
hsa-let-7g/Upstream/4087960; hsa-mir-3137/Downstream/1216537;
Nearest TSS
ENST00000440867/Upstream/73945; ENST00000426616/Downstream/62645;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/47869, chr3-CpG: 36/Downstream/85195
Nearby gene
OPA1(-220158) ; LINC02026(+39403) ;
Upstream sequence
GCAAGatattttaaaattgtaaaaatattattaaaGAAAGCTTATTGATTAGTACATGTCTCTTACAGGTGGTATAAAGGAACTTTACAGAAAAGTGTAA
Downstream sequence
CACTCTGAGTATTCAGAGTGAGAATCATTGCATGTTTAAAATGACTTGAGCTGTGCTGGCTTTTTGGTCCCGCAGCCTTTTCAAACGATGCTTGAAATTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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