Basic Information
VIS ID
TVIS10011576
Fusion event
HBV-LOC105374287 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1798
Orient
-
Integrated sequence
TGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTG| |GTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTG
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
193635787/193917998 (Hg38)
End
193635787/193917998 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374287
Nearest miRNA
hsa-let-7g/Upstream/4087989; hsa-mir-3137/Downstream/1216508;
Nearest TSS
ENST00000440867/Upstream/73974; ENST00000426616/Downstream/62616;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/47898, chr3-CpG: 36/Downstream/85166
Nearby gene
OPA1(-220187) ; LINC02026(+39374) ;
Upstream sequence
TGGGGTTTCCCAAAGTCATTCACCCAGGTTAGTGACTCATGTCTCCACACACTAATCTCAGAGCACATGCAAATTTAGGCATGACCAGAACACACAcatt
Downstream sequence
GCATGTTTAAAATGACTTGAGCTGTGCTGGCTTTTTGGTCCCGCAGCCTTTTCAAACGATGCTTGAAATTGTTTTTTTTCAAACCAATCTTTTCAAAAAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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