VISDB Viral Integration Site DataBase

VIS ID

TVIS10011582

Fusion event

HBV-ARHGEF3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2000

Orient

+

Integrated sequence

GCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATAC| |CGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATG

Chromosome

chr3

Cytoband

p14.3

Reference genome

Start

End

56905092/56871064 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-373-3p ; hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-377-5p ; hsa-mir-485-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-889-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p

Nearest miRNA

hsa-let-7g/Upstream/1018470; hsa-mir-12124/Downstream/3746741;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/68882, chr3-CpG: 112/Downstream/207657

Upstream sequence

ACCAAGTTGGAATTATATAGTACATATTTTCTTTGAAAATAAATACATCAAGGACACTTTTAAACCTTCTTAATTATTGTTTTCAAACTTGTAAAAAAAC

Downstream sequence

AGTAAACTGATTATTACACCTAAGGAGGTAAGTGGGACTGGGGCATGGTAGAGTCACTGTTAGCTCTATCTCTGCTGTTTGATTTTTAAATGATGAGAAT