Basic Information
VIS ID
TVIS10011585
Fusion event
HBV-LINC01266 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2419
Orient
+
Integrated sequence
CTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTC| |GCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTA
Host Sequence
Chromosome
chr3
Cytoband
p26.3
Reference genome
GRCh37/hg19
Start
808045/766362 (Hg38)
End
808045/766362 (Hg38)
Orient
+
Location type
Intronic
Target gene
LINC01266
Nearest miRNA
hsa-let-7g/Downstream/4483815;
Nearest TSS
ENST00000440867/Upstream/230109; ENST00000423193/Downstream/90762;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/457152, chr3-CpG: 182/Downstream/1331983
Nearby gene
CHL1(-356948) ; CNTN6(+326584) ;
Upstream sequence
GATCATGAGAACACTACTTACACCAAAGAACATGTCTTGATAGCTTCAAGTGCTGTGTTTAAAAAGATGTAACAGAGAAACTCTATGTTTGAACGCAAAA
Downstream sequence
aggtggtcatttattatggtatccctagtaaaAAAAAAATATTCTGGATAGTTTGGTAATTCTCATTTATAAAACTATTTATcggtgaaaccccatctct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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