Basic Information
VIS ID
TVIS10011587
Fusion event
HBV-LOC100507053 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr4
Cytoband
q23
Reference genome
GRCh37/hg19
Start
100022883/99101732 (Hg38)
End
100022883/99101732 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC100507053
Nearest miRNA
hsa-mir-12113/Upstream/104272; hsa-mir-1243/Downstream/2139063;
Nearest TSS
ENST00000502981/Upstream/12781; ENST00000506454/Downstream/34805;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/12754, chr4-CpG: 40/Downstream/461838
Upstream sequence
gtaatcccagctactttggaggacaaggcaggagaatcacctgaacctgggaggtagaggttgcagtgagccgtgatcacgctattgcaatctagcctgg
Downstream sequence
TGGTGAAAGCCAAGGACTGAATGCAGGTCTTAAATGGCCAGTTGTGGAAAGAATCATCCTTATAAAAGAATTGAGATAGGAGATCTCTAATAGAGGAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate