Basic Information
VIS ID
TVIS10011597
Fusion event
HBV-LOC105379412 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr4
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
140135234/139214080 (Hg38)
End
140135234/139214080 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105379412
Nearest miRNA
hsa-mir-12113/Upstream/13706773; hsa-mir-1305/Downstream/4129380;
Nearest TSS
ENST00000502981/Upstream/36862; ENST00000482087/Downstream/66258;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/35398, chr4-CpG: 41/Downstream/65830
Nearby gene
ELF2(-74628) ; MGARP(+52083) ;
Upstream sequence
ttcaagcgattctcctgcctcagcctcccgagtagctgggattacaggcatgcaccaccacacccagctaattttttggatttttagtagagatggggtt
Downstream sequence
AGAGAGCCTGGATCTGCAGGTGTTCGGCTGCCTCATGGGCCACTGTTGGCCACTCTGAGATCCGCTTCATTACTGTGAACACAGACCAAGGTCCTGCATT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate