Basic Information
VIS ID
TVIS10011599
Fusion event
HBV-LOC101927947 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
-
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154817121/153895969 (Hg38)
End
154817121/153895969 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101927947
Nearest miRNA
hsa-mir-12113/Upstream/1359453; hsa-mir-1305/Downstream/5232833;
Nearest TSS
ENST00000502981/Upstream/106849; ENST00000625026/Downstream/246153;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/102881, chr4-CpG: 39/Downstream/437009
Nearby gene
SFRP2(-106893) ; DCHS2(+338406) ;
Upstream sequence
AATTCTTTTGTATTTTACTGGAATTACACTGTGTGCACttttttaaaatttaaaaatttatatttataCCTTTCCTTGACAACAAGTATATTCTATTTTC
Downstream sequence
AGTAAGATCTGCCGAGATTCTGGGCTGCACCTTTCTACTGTTGAAAGTCTTTTATAACCTGGCTAGGAATTAGGCAGCTTTTAAATTTGGCAGGTCTCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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