Basic Information
VIS ID
TVIS10011600
Fusion event
HBV-LOC101927947 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2369
Orient
+
Integrated sequence
GAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCC| |TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA
Host Sequence
Chromosome
chr4
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
154817279/153896127 (Hg38)
End
154817279/153896127 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927947
Nearest miRNA
hsa-mir-12113/Upstream/1359611; hsa-mir-1305/Downstream/5232675;
Nearest TSS
ENST00000502981/Upstream/107007; ENST00000625026/Downstream/245995;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/103039, chr4-CpG: 39/Downstream/436851
Nearby gene
SFRP2(-107051) ; DCHS2(+338248) ;
Upstream sequence
acacaaaaataaacatcaagaaactaaattatatcacaagataaaatcaccttcactagaggaagagaggatggaaagaaacaagaaagagaagaccaca
Downstream sequence
CTTGTGGGTTTCAATTAGGATTGTTATAGAATTAGGTGAGGATGGAAATTAGATTAATGTAAAGAAACAACAGCAAAGATACTATGTTAGAAAATGTATG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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