Basic Information
VIS ID
TVIS10011601
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1932
Orient
+
Integrated sequence
CTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGA| |GCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGT
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
167136618/166215466 (Hg38)
End
167136618/166215466 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/829129; hsa-mir-1305/Downstream/4970718;
Nearest TSS
ENST00000502981/Upstream/340508; ENST00000503003/Downstream/310653;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/341277, chr4-CpG: 27/Downstream/2102932
Nearby gene
TLL1(-111009) ; SPOCK3(+517918) ;
Upstream sequence
aactaaattatatcacaagataaaatcaccttcactagaggaagagaggatggaaagaaacaagaaagagaagaccacaaaacaacagaagacaaatagc
Downstream sequence
AAAATATAGAGGGCTTCATGCTTTAATTAATAGTTCCTTTTTTATTTTTAAATATTTGGTCTGCAGTTAAGTTTTAATTGTCAATTTATATTTGGCTCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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