Basic Information
VIS ID
TVIS10011609
Fusion event
HBV-CCSER1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
92355735/91434584 (Hg38)
End
92355735/91434584 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
CCSER1
miRNAs that regulate target gene
hsa-mir-544a
Nearest miRNA
hsa-mir-12113/Upstream/4134001; hsa-mir-1243/Downstream/7562803;
Nearest TSS
ENST00000502981/Upstream/109278; ENST00000505511/Downstream/453302;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/595468, chr4-CpG: 26/Downstream/747882
Upstream sequence
GGTGCCATCCTGCAGGGTCCCCCGAGGATTGCCTAGACTGGGCAGTGCAATACACAGACACACAAAGGCATGAGACAGGAGCATAAGTAATGTGCAAACT
Downstream sequence
ATGTAATTATGCATAGTAAGAATATCCACAGCTTTCCATAACTGGTATGAAGATTGATGGCAGTTTTTTCTGTTTTATCTATTTTATCTCATAAATATTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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