VISDB Viral Integration Site DataBase

VIS ID

TVIS10011610

Fusion event

HBV-MCC integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2445

Orient

+

Integrated sequence

TGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCT| |CAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTT

Chromosome

chr5

Cytoband

q22.2

Reference genome

Start

End

112680197/113344500 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-494-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-219b-5p ; hsa-mir-3973 ; hsa-mir-5692a ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-2355-5p ; hsa-mir-1306-5p ; hsa-mir-4687-5p ; hsa-mir-548aw ; hsa-mir-4451 ; hsa-mir-379-5p ; hsa-mir-3529-5p ; hsa-mir-6716-5p ; hsa-mir-4650-3p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-4790-3p ; hsa-mir-548aj-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-526b-3p ; hsa-mir-20a-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-17-5p ; hsa-mir-301b-3p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-130a-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-19b-3p ; hsa-mir-19a-3p

Nearest miRNA

hsa-mir-10397/Upstream/2830585; hsa-mir-103a-1/Downstream/2911243;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/49573, chr5-CpG: 86/Downstream/143059

Nearest cancer related gene

MCC(OG, No orient, 0)

Upstream sequence

aggctggactgcagtggtgcgatcttggctcactgcaacatccaactccctggttcaagcaattcccctgcctcagcctcttgagtagctagaattacaa

Downstream sequence

cacagcttgcagcaaagaaagtgacttgttccttctgcttgaggagaggagagagaagagtaaagaggatttggttttgcatcttggaaaccagctcagc