Basic Information
VIS ID
TVIS10011615
Fusion event
HBV-LOC105377722 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1860
Orient
+
Integrated sequence
TAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCT| |ACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGC
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
171009614/171582610 (Hg38)
End
171009614/171582610 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
LOC105377722
Nearest miRNA
hsa-mir-10397/Upstream/195850; hsa-mir-10523/Downstream/1079555;
Nearest TSS
ENST00000502646/Upstream/162954; ENST00000524175/Downstream/191042;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/125778, chr5-CpG: 23/Downstream/47457
Nearby gene
FGF18(-124984) ; FBXW11(+278942) ;
Upstream sequence
CCTCCTCAACATACAGTACAGTTATTTACATGACAATGGGCACCCATTTCCATGGTACCTAGTGAAATACTTAACACATCATAGTTATGTTAAATAAATG
Downstream sequence
AGTCCATGGAGATCTCTTCCTAGGATAGCACGttagtcaggactctttagatggcaaggacagacactaactcaatctgtcttaataaatgaacaaagga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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