Basic Information
VIS ID
TVIS10011616
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1811
Orient
-
Integrated sequence
AAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAG| |CACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATC
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
172192765/172765762 (Hg38)
End
172192765/172765762 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/103499; hsa-mir-10523/Downstream/149321;
Nearest TSS
ENST00000502646/Upstream/2782; ENST00000518260/Downstream/5433;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16882, chr5-CpG: 172/Downstream/4717
Nearby gene
NEURL1B(-74232) ; DUSP1(+2328) ;
Nearest cancer related gene
DUSP1(TSG, +2328) ;
Upstream sequence
TTCCTTACCATTTGCTCATGGCGTGCTGCCTGCCTAGAACCTTCTCTCATTTCACTGTCTTTATCCCATCCAATGTCTAAAAGATACTGTAAACTCTACT
Downstream sequence
TAATGTATGCATTGATGCATTTTCTACatcccagaattagagagatgggaagaacagtactcagatccagtgcaaattggtcattttacggggtgggaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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