Basic Information
VIS ID
TVIS10011617
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2023
Orient
+
Integrated sequence
GAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAG| |CCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGT
Host Sequence
Chromosome
chr5
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
172192806/172765803 (Hg38)
End
172192806/172765803 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5G
Nearest miRNA
hsa-mir-10397/Upstream/103540; hsa-mir-10523/Downstream/149280;
Nearest TSS
ENST00000502646/Upstream/2823; ENST00000518260/Downstream/5392;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16923, chr5-CpG: 172/Downstream/4676
Nearby gene
NEURL1B(-74273) ; DUSP1(+2287) ;
Nearest cancer related gene
DUSP1(TSG, +2287) ;
Upstream sequence
ccctgcagcagctctctgttatatcctcagagcctctcaacagtgcttttggtaaataagtgctcaagaaatattcattgagtaaaGAACTAAGTTAGAA
Downstream sequence
gagatgggaagaacagtactcagatccagtgcaaattggtcattttacggggtgggaaaactgagccagaAGAACTGCCAGAAGCCATTAGGACAGAGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate