Basic Information
VIS ID
TVIS10011619
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1816
Orient
-
Integrated sequence
CTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCA| |TGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCC
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
87257742/87961925 (Hg38)
End
87257742/87961925 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/846971; hsa-mir-103a-1/Downstream/704928;
Nearest TSS
ENST00000502646/Upstream/228656; ENST00000504636/Downstream/236526;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/548864, chr5-CpG: 30/Downstream/179353
Nearby gene
CCNH(-548892) ; TMEM161B(+233281) ;
Upstream sequence
ATCCATCTCCCCTCCTGACCATAGCCCTACTTTCTCCCTAAGGAGATTGTGTCCCCAAGCCGTCATATAACTGCCACAGGCATGCTTGCAGCATCTGAGT
Downstream sequence
tacttgtcatttttggattcagcctcccctgatgacctgactttaacttgatgacctctataaagaccttatttgcaaataaggtcacatgctttctttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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