Basic Information
VIS ID
TVIS10011620
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3110
Orient
+
Integrated sequence
GGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAAT| |CGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
122480269/122159123 (Hg38)
End
122480269/122159123 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/2143866; hsa-mir-1202/Downstream/4325508;
Nearest TSS
ENST00000381078/Upstream/723431; ENST00000465214/Downstream/240423;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/824247, chr6-CpG: 95/Downstream/240339
Nearby gene
GJA1(-709396) ; HSF2(+240427) ;
Nearest cancer related gene
GJA1(TSG, -709396) ;
Upstream sequence
atttctcaaacaatttgcaagaaataacaaaatctatccagtaaggatagtaactacaatcccaaatagactctttggcagcagtgactctccaaaactg
Downstream sequence
TATTAACAACAGGCTAATATCCACGAAATGCCAAAGGGTAAAATTAATACTCAGTTGCAAGTATAACCCAATCTATAAGATCATCACTAGAGCCACCCTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate