Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10011621
Fusion event
HBV-NKAIN2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1829
Orient
+
Integrated sequence
GACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCA| |CCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTT
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
End
125035779/124714633 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10398/Upstream/4699376; hsa-mir-1202/Downstream/1769998;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/910469, chr6-CpG: 128/Downstream/247345
Upstream sequence
ttcactcacagtggtagctggtttcataatgcactcttgattggctgttttctgttccttgtttctattccccagtcctttgccatggttccctgtattg
Downstream sequence
CAGGCCGTCTAAAGAAGAAAGTGGTGTACTTACAGATCTAATTTTCATCTGAGCATAGTACATTGTAGTTCCCTGAGGCAGGCTTTGATATCACAAAAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.