Basic Information
VIS ID
TVIS10011623
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1799
Orient
-
Integrated sequence
GAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGG| |TCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGG
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
148894083/148572947 (Hg38)
End
148894083/148572947 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/7889064; hsa-mir-1202/Downstream/2529728;
Nearest TSS
ENST00000381078/Upstream/45682; ENST00000473631/Downstream/174381;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/12642, chr6-CpG: 157/Downstream/173869
Nearby gene
SASH1(-20899) ; UST(+174188) ;
Nearest cancer related gene
SASH1(TSG, -20899) ;
Upstream sequence
TGACTTTCAGGAATAAAGCTGTATTTTCTTCTTAAAGTAGCAATATGCCTTCTTTTGCTCTAGCCTGTGGGGACAGCTAATTTTCTGTTCTTCTAAAAGT
Downstream sequence
gggcaggagcagggctgagaccccctcagttataagatgcagcctaacttctgagattttcaagtgtcaaaaaactatacgtcttagGGATAGTAAAGCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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