Basic Information
VIS ID
TVIS10011625
Fusion event
HBV-LOC105374955 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
18504918/18504687 (Hg38)
End
18504918/18504687 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105374955
Nearest miRNA
hsa-mir-3691/Upstream/2363063; hsa-mir-10398/Downstream/67097;
Nearest TSS
ENST00000381078/Upstream/117173; ENST00000636739/Downstream/18052;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/117072, chr6-CpG: 36/Downstream/1186992
Nearby gene
RNF144B(-35813) ; MIR548A1(+67097) ;
Upstream sequence
GTGACATTGTTTGTGACTGGAGTGCTACCTGAGTAAATTATCATGATTACATGAAAAGCAATTAAGAGAAGAAGGTCAAAGGACCAACCTCTAATCACTA
Downstream sequence
GTTAGGGAATTCTTCTCTTATTTCCACAGAGGCAGGTAGCCTGAGCATGGGGGATATACACCTTTAAGAGACAAATACCAATCCAGTTCTTTACAAAGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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