Basic Information
VIS ID
TVIS10011626
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1895
Orient
+
Integrated sequence
TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT| |TTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTA
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
27772353/27804575 (Hg38)
End
27772353/27804575 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3143/Upstream/656887; hsa-mir-10398/Downstream/2779757;
Nearest TSS
ENST00000381078/Upstream/110496; ENST00000358739/Downstream/3356;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/46855, chr6-CpG: 69/Downstream/2976
Nearby gene
LOC100131289(-41387) ; HIST1H2BL(+2904) ;
Upstream sequence
AGGTGAAACCCCAATCCATAGACAGCCCGCCAGCAGGTTGAGGCAGGACCACTAGGAGGAGACTGTGCTCAAGCACAGAGAGGGCCCTTTAGGTTTCAAA
Downstream sequence
acaaaaaaCAATGCTCTATTTGACATATCTCTTTTTAACTGGTGACAAATACTTGTAAGAGTCTAAAAGAGACTAATAGTACTTTCTTTTGCTTTTTCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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