Basic Information
VIS ID
TVIS10011627
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1823
Orient
-
Integrated sequence
TTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACT| |TTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAA
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
27772555/27804777 (Hg38)
End
27772555/27804777 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3143/Upstream/657089; hsa-mir-10398/Downstream/2779555;
Nearest TSS
ENST00000381078/Upstream/110698; ENST00000358739/Downstream/3154;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/47057, chr6-CpG: 69/Downstream/2774
Nearby gene
LOC100131289(-41589) ; HIST1H2BL(+2702) ;
Upstream sequence
TATAGATTATTTTAGTCAGAAACAGAGGCCTGGGCACCAATTTGGGTGTGAAGATAAGAATAAGGGAGTTCAGAATTCAATTAACTTGAATCATTGCTGT
Downstream sequence
AAATAGTGTTAAATTGGCATCTGGAATTATGTGTAAAATATTTCAGAATCTCACTTAGTAAGTCCTTCTCAGATTATATCTAGTTGTTTTATCCTGAAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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