VISDB Viral Integration Site DataBase

VIS ID

TVIS10011630

Fusion event

HBV-PTK7 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|precore/core protein|

Start

1821

Orient

+

Integrated sequence

TGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAA| |CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATA

Chromosome

chr6

Cytoband

p21.1

Reference genome

Start

End

43044568/43076830 (Hg38)

Orient

+

Location type

UTR5

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-193b-3p ; hsa-mir-324-5p ; hsa-mir-92a-3p ; hsa-mir-218-5p ; hsa-mir-190a-3p ; hsa-mir-6083 ; hsa-mir-5689 ; hsa-mir-3141 ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-1265 ; hsa-mir-185-5p ; hsa-mir-2110 ; hsa-mir-2392 ; hsa-mir-3154 ; hsa-mir-3915 ; hsa-mir-3928-3p ; hsa-mir-4271 ; hsa-mir-4306 ; hsa-mir-4428 ; hsa-mir-4644 ; hsa-mir-4725-3p ; hsa-mir-491-5p ; hsa-mir-651-5p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-6770-5p ; hsa-mir-6780b-5p ; hsa-mir-6863 ; hsa-mir-92a-2-5p

Nearest miRNA

hsa-mir-10398/Upstream/1343220; hsa-mir-10524/Downstream/357712;

Nearest TSS

Nearest CpG islands

chr6-CpG: 104/Target, None/Upstream, None/Downstream

Nearest cancer related gene

PTK7(OG, No orient, 0)

Upstream sequence

gaactccagcacatcgatgcagggggtgtcctgcggccattaaaGTGACAGGTCTGAGGGCTCAGTCAATAGCAGGAGACGTGTGTAGGAGATAAAGGCA

Downstream sequence

TGAGCCGAGAGTTTGCTCGAGAACTGCCGAGAGTTGCTGGCTCTCGGGCCCAGATGGGGAGTTTCTTGTCGGGGGAGAAAAGACCATCCGCACCCACCGT