Basic Information
VIS ID
TVIS10011632
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3181
Orient
-
Integrated sequence
CAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTG| |G
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
72418206/71708503 (Hg38)
End
72418206/71708503 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/304882; hsa-mir-10524/Downstream/1259184;
Nearest TSS
ENST00000381078/Upstream/257669; ENST00000370419/Downstream/178200;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/119678, chr6-CpG: 64/Downstream/177830
Nearby gene
LINC00472(-287758) ; RIMS1(+178200) ;
Upstream sequence
tgggttggggttgaggatgaacccagtctggaatctgagtccACTGTATACCCATGAGGCCTGTCTGTACCGTgcaagagagcaaatgtaggtctacaag
Downstream sequence
ctgttccttttctattctttatctaatgaagtaaatgccactgccctccacccataaatttgagccaaaacccaatgaaacatccttgaaggttctcttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate