Basic Information
VIS ID
TVIS10011633
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1818
Orient
+
Integrated sequence
GTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATG| |CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT
Host Sequence
Chromosome
chr7
Cytoband
q31.31
Reference genome
GRCh37/hg19
Start
118395816/118755762 (Hg38)
End
118395816/118755762 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/1735443; hsa-mir-10399/Downstream/8302326;
Nearest TSS
ENST00000635602/Upstream/515787; ENST00000421825/Downstream/1151613;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/541095, chr7-CpG: 93/Downstream/1517024
Nearby gene
ANKRD7(-513032) ; KCND2(+1517906) ;
Upstream sequence
CGCTGGTCCCTTGGATCAGAAATTCAGTACCCTTCCCTCCACACCATGCTGTAGACACCTCTTTCCTCTCCTAGACCCGGAACATCCTCTCTTCTTCAGG
Downstream sequence
GTTATGATTTATGTGTCATTTATTTTAGTACTAATATAGTTAGCATTGGAGCATATGAATGCTAAATCCTCTGAAAGTTAGTGGGTTTTCATCTTAAGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate