Basic Information
VIS ID
TVIS10011637
Fusion event
HBV-LOC105375605 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2108
Orient
+
Integrated sequence
CTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGC| |TACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGG
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
156735576/156942882 (Hg38)
End
156735576/156942882 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
LOC105375605
Nearest miRNA
hsa-mir-10399/Upstream/5509243; hsa-mir-153-2/Downstream/631454;
Nearest TSS
ENST00000635602/Upstream/49652; ENST00000427073/Downstream/1839;
Nearest CpG islands
chr7-CpG: 32/Target, None/Upstream, None/Downstream
Nearby gene
LMBR1(-49674) ; NOM1(+6841) ;
Upstream sequence
aaatgttcatactacccagagcaatctatagattcaatgcaatctctatcaaaataccaatgatatttttcacataaatagaacaaacaatcataaaatt
Downstream sequence
TGGGCGGGAGGAGAGCTCTCCCGCTCCGCTGACTCACCTGGCGGCCTTGACACACAGAAACAGGCCCCAGCTGAAGGTGCGGCGGGCCGGCACCCTCCTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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