Basic Information
VIS ID
TVIS10011639
Fusion event
HBV-MIR148A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr7
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
25989457/25949837 (Hg38)
End
25989457/25949837 (Hg38)
Orient
+
Location type
downstream
Target gene
MIR148A
Nearest miRNA
hsa-mir-1183/Upstream/4478691; hsa-mir-10399/Downstream/82;
Nearest TSS
ENST00000635602/Upstream/434; ENST00000607375/Downstream/202403;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/90686, chr7-CpG: 111/Downstream/555
Nearest cancer related gene
MIR148A(TSG, No orient, 0)
Upstream sequence
CCCCAAACAACTCAGAAATAAGCTACCGAAAATAGTCTTTTAGAATATGCTTCCATTGGGTAGCACCTTCAATCTCAGGAATCAGAAATACTATGTAAAG
Downstream sequence
GGAAAGGCGCAGCGACGTGGCCACCAGGGCCACTCGGCCTGGCGTCTGGAGCACTGGCGGCATCGGCGACCACAGCCTCTAGAGACAAAGTTCTGTAGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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