Basic Information
VIS ID
TVIS10011640
Fusion event
HBV-MIR148A integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
934
Orient
-
Integrated sequence
TAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAA| |AATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACA
Host Sequence
Chromosome
chr7
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
25989579/25949959 (Hg38)
End
25989579/25949959 (Hg38)
Orient
-
Location type
ncRNA_exonic
Target gene
MIR148A
Nearest TSS
ENST00000635602/Upstream/556; ENST00000607375/Downstream/202281;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/90808, chr7-CpG: 111/Downstream/433
Nearest cancer related gene
MIR148A(TSG, No orient, 0)
Upstream sequence
acctctttgagggcttcgttgcaaacggggtttcttcctttcatgctagactaagaagagttctcaggaacttttttgtgttgtgtgtattcaactcaca
Downstream sequence
AGTCGGAGTGTCTCAGAACTTTGCCTCAAAAGACCAAACGTGCTGTCTTCCTCCAGAAGTTTCTTCCTGCAGGTGTGTTCCCCCACCCCCCAGCTAAGAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate