Basic Information
VIS ID
TVIS10011647
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2306
Orient
+
Integrated sequence
GGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACC| |AAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCT
Host Sequence
Chromosome
chr8
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
5162318/5304796 (Hg38)
End
5162318/5304796 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3674/Upstream/3228156; hsa-mir-10400/Downstream/1317328;
Nearest TSS
ENST00000518652/Upstream/309824; ENST00000522905/Downstream/204330;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/181372, chr8-CpG: 72/Downstream/1101265
Nearby gene
CSMD1(-309990) ; LOC100287015(+1098759) ;
Nearest cancer related gene
CSMD1(TSG, -309990) ;
Upstream sequence
ACAGGTGAGTGAAGCAGAGATTCCTATGTAGATTTTCTTATCCCTGAATTTTAGATTGTGATATGTCCACAAGGACTGCTGGGACCTCAGTTTCATAGGC
Downstream sequence
GTGGCGCAATAGGAAATTACCGTTGCAATGGAATCAGTAAATCACATTCAAATCACTGAGAGTGCAAACTCGAGAAGTACTTCAAAATTTTGCCTAAAAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate