Basic Information
VIS ID
TVIS10011651
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2297
Orient
+
Integrated sequence
AACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTA| |TAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGA
Host Sequence
Chromosome
chrX
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
142672882/143585057 (Hg38)
End
142672882/143585057 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/2658826; hsa-mir-105-1/Downstream/2407693;
Nearest TSS
ENST00000429181/Upstream/67582; ENST00000423667/Downstream/49446;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/2407837, chrX-CpG: 130/Downstream/48537
Nearby gene
SPANXN3(-67575) ; SLITRK4(+37713) ;
Upstream sequence
gttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggtga
Downstream sequence
acagagagtgagtaagatgcttttaatgaggtagaaagaaaaataagaaaacatgcaagcagaagccaggacaggagagaagcgaatggtcagcgatgtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate